Depression and the HPA Axis

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Here’s what you need to know about depression and the HPA axis.

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0:00 What is the HPA axis?
0:57 Cortisol
1:30 The HPA axis and depression
2:52 Natural remedies for depression from chronic stress
5:08 Bulletproof your immune system *free course!

Today we’re going to talk about depression and the HPA axis.

H – Hypothalamus
P – Pituitary
A – Adrenals

There is a feedback loop of communication between the hypothalamus, pituitary, and the adrenals. This communication turns certain hormones on and off. If cortisol (a stress hormone) is constantly stimulated and turned on by chronic stress, it could lead to burnout.

Cortisol can affect the hippocampus in the brain, which involves memory and learning. High levels of cortisol over time can potentially shrink the hippocampus affecting your memory.

If the sympathetic nervous system and the fight or flight mechanism are overstimulated over time, it can cause someone to experience anxiety and then depression. On the flip side, if the parasympathetic nervous system is dysregulated, it can cause someone to develop depression.

Potential remedies for depression from chronic stress:
1. Reduce stress
2. Magnesium
3. Fasting (combine this with ketones)
4. Aerobic exercise
5. Vitamin D
6. Rhodiola
7. Get plenty of sleep
8. Vitamin B1 (from nutritional yeast)

Dr. Eric Berg DC Bio:
Dr. Berg, age 55, is a chiropractor who specializes in Healthy Ketosis & Intermittent Fasting. He is the author of the best-selling book The Healthy Keto Plan, and is the Director of Dr. Berg Nutritionals. He no longer practices, but focuses on health education through social media.


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Dr. Eric Berg received his Doctor of Chiropractic degree from Palmer College of Chiropractic in 1988. His use of “doctor” or “Dr.” in relation to himself solely refers to that degree. Dr. Berg is a licensed chiropractor in Virginia, California, and Louisiana, but he no longer practices chiropractic in any state and does not see patients so he can focus on educating people as a full time activity, yet he maintains an active license. This video is for general informational purposes only. It should not be used to self-diagnose and it is not a substitute for a medical exam, cure, treatment, diagnosis, and prescription or recommendation. It does not create a doctor-patient relationship between Dr. Berg and you. You should not make any change in your health regimen or diet before first consulting a physician and obtaining a medical exam, diagnosis, and recommendation. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. The Health & Wellness, Dr. Berg Nutritionals and Dr. Eric Berg, D.C. are not liable or responsible for any advice, course of treatment, diagnosis or any other information, services or product you obtain through this video or site.

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Thanks for watching! I hope this helps you better understand depression and the HPA axis.
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